Statistical mechanics of disordered many-particle systems.
Processes on complex networks and random graphs. Mathematical
bio-medicine.
Topics and projects
- Development and application of
dynamical methods (generating functional analysis, dynamical replica method) for complex many-particle
systems
-
Analysis of sparse random graph ensembles
-
Equilibrium and non-equilibrium
theory of processes on complex finitely connected graphs
-
Theory of
primary/secondary/tertiary structure generation in hetero-polymers
and proteins
-
Calculation of the stationary
state probability distribution for non-detailed balance spin
systems
-
Dynamics of econophysical models
such as minority games, describing cooperative phenomena in
markets.
-
Dynamics and statics of large
immune system networks in the finite connectivity regime
-
Theory of cellular
signaling processes in e.g. proteomic, gene regulatory, and metabolic networks
-
Medical statistics, Bayesian
analysis of survival data in presence of cohort heterogeneity
and competing risks
I am involved in
the creation of a multidisciplinary research and teaching
infrastructure at King's College London, to combine and exploit expertise at the
interfaces between biology, medicine, physics, computer science and
mathematics. See the websites of the
Institute for Mathematical and Molecular Biomedicine and the
Systems Biomedicine Graduate Programme for further details.
Research and review papers
There is a full list of my
publications, and you can find PDFs of
recently published papers (from 2000 onwards),
either organized by year or
by topic.
In addition the following recent preprint(s) can be downloaded:
- N Shayeghi, T Ng and ACC Coolen
Direct response analysis in cellular signalling networks
(to be published in Journal of Theoretical Biology, PDF)
- ES Roberts and ACC Coolen
Unbiased degree-preserving randomization of directed binary networks
(to be published in Physical Review E, PDF)
Books
ACC Coolen
The
Mathematical theory of minority games - statistical mechanics of
interacting agents
(Oxford University Press, January 2005)
(click here for preface and
detailed list of contents)
ACC Coolen, R Kuehn and P Sollich
Theory
of neural information processing systems
(Oxford University Press, July 2005)
(click here
for preface and detailed list of contents)
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Recent research seminars
- Utrecht,
22 December 2003
"The trick which became a theory: a
brief history of the replica method"
- Nara,
21 January, and Tokyo, 3 February 2004
"Disordered
(soft) spin systems on random graphs with finite connectivity"
- Heidelberg,
1 April 2004
"Simple solvable models of primary and
secondary structure formation in hetero-polymers"
- Oxford,
27 September 2004, and Amsterdam, 12 November 2004
"Generating
functional analysis of minority games with real market histories"
- Leiden,
26 May 2005
"Theory of coupled oscillators on finitely
connected random networks"
- Barcelona,
3 June 2005
"Statistical mechanics of signalling
processes on complex biological networks"
- Leuven,
10 June 2005
"Generating functional analysis of
minority games with inner product strategy definitions"
- Leuven,
8 August 2005
"Finitely connected vector spin systems
with random matrix interactions"
- Cambridge,
10 Jan 2006
"Dynamics on finitely connected random
graphs"
- Oxford,
27 Sept 2006
"Generating functional analysis of inner
product minority games"
- Fribourg,
8 Nov 2007
"Applications of generating functional
analysis to minority game models"
- Trieste,
16 Jan 2008
"Spin models on random graphs with
controlled topologies beyond degree constraints"
- Rome,
13 Feb 2008
"A solvable model of the genesis of
amino-acid sequences via coupled dynamics of folding and slow
genetic variation"
- Kyoto,
16 Sep 2009
"Generating functional analysis of complex
formation and dissociation in large protein interaction networks"
- London, 21 Oct 2009
"Protein interaction networks viewed through
statistical mechanical glasses"
- Stockholm (NORDITA), 22 June 2010, and Rome (La Sapienza), 1 July 2010
"Tailoring, counting, and generating sructured random graphs"
- Dublin, 22 June 2011
"Analysis of signalling in large protein interaction networks"
- Evora (Portugal), 16 Sept 2011
"Controlled Markovian dynamics of graphs"
- London, 21 Feb 2012, 26 March 2012
"What you see is not what you get: how sampling affects macroscopic features of
biological networks"
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