Mathematical biomedicine and survival analysis.
Statistical mechanics of disordered manyparticle systems.
Processes on complex networks and random graphs.
Topics and projects

Medical statistics: Bayesian
analysis of survival data in presence of cohort heterogeneity
and competing risks
 Mathematical immunology:
dynamics and statics of large
immune system networks in the finite connectivity regime

Theory of cellular
signaling processes in e.g. proteomic, gene regulatory, and metabolic networks

Analysis of sparse random graph ensembles

Equilibrium and nonequilibrium
theory of processes on complex finitely connected graphs

Theory of
primary/secondary/tertiary structure generation in heteropolymers
and proteins

Calculation of the stationary
state probability distribution for nondetailed balance spin
systems

Dynamics of econophysical models
such as minority games, describing cooperative phenomena in
markets.
I am involved in
the creation of a multidisciplinary research and teaching
infrastructure at King's College London, to combine and exploit expertise at the
interfaces between biology, medicine, physics, computer science and
mathematics. See the websites of the
Institute for Mathematical and Molecular Biomedicine and the
Systems Biomedicine Graduate Programme. A brief nontechnical introduction to the role of mathematics
in cancer research can be found
here.
Research and review papers
There is a full list of my
publications, and you can find PDFs of
recently published papers (from 2000 onwards),
either organized by year or
by topic.
In addition the following recent preprint(s) can be downloaded:
 J van Baardewijk, H Garmo, M van Hemelrijck, B Grundmark, B Zethelius, L Holmberg and ACC Coolen
Practical tools for survival analysis with heterogeneityinduced competing risks
(submitted to Statistics in Medicine, PDF)
 J Barrett and ACC Coolen
Gaussian process regression for survival data with competing risks
(submitted to Statistics in Medicine, PDF)
 J Barrett and ACC Coolen
Covariate dimension reduction for survival data via the Gaussian process latent variable model
(submitted to Statistics in Medicine, PDF)
 ES Roberts and ACC Coolen
Random graph ensembles with many short loops
(ESAIM Proceedings, in press, PDF)
 A Shalabi, M Inoue, J Watkins, E De Rinaldis and ACC Coolen
Bayesian clinical classification from highdimensional data: signatures versus variability
(submitted to Statistics in Medicine, PDF)
Books
ACC Coolen The
Mathematical theory of minority games  statistical mechanics of
interacting agents
(Oxford University Press, January 2005)
(click here for preface and
detailed list of contents)
ACC Coolen, R Kuehn and P Sollich
Theory
of neural information processing systems
(Oxford University Press, July 2005)
(click here
for preface and detailed list of contents)
in preparation:
ACC Coolen and L Holmberg
Principles of survival analysis
(Oxford University Press, 2013/14)
in preparation:
ACC Coolen, A Annibale and K Roberts
Generating random networks and graphs
(Oxford University Press, 2013/14)

Recent research seminars
 Utrecht,
22 December 2003
"The trick which became a theory: a
brief history of the replica method"
 Nara,
21 January, and Tokyo, 3 February 2004
"Disordered
(soft) spin systems on random graphs with finite connectivity"
 Heidelberg,
1 April 2004
"Simple solvable models of primary and
secondary structure formation in heteropolymers"
 Oxford,
27 September 2004, and Amsterdam, 12 November 2004
"Generating
functional analysis of minority games with real market histories"
 Leiden,
26 May 2005
"Theory of coupled oscillators on finitely
connected random networks"
 Barcelona,
3 June 2005
"Statistical mechanics of signalling
processes on complex biological networks"
 Leuven,
8 August 2005
"Finitely connected vector spin systems
with random matrix interactions"
 Cambridge,
10 Jan 2006
"Dynamics on finitely connected random
graphs"
 Oxford,
27 Sept 2006
"Generating functional analysis of inner
product minority games"
 Fribourg,
8 Nov 2007
"Applications of generating functional
analysis to minority game models"
 Trieste,
16 Jan 2008
"Spin models on random graphs with
controlled topologies beyond degree constraints"
 Rome,
13 Feb 2008
"A solvable model of the genesis of
aminoacid sequences via coupled dynamics of folding and slow
genetic variation"
 Kyoto,
16 Sep 2009
"Generating functional analysis of complex
formation and dissociation in large protein interaction networks"
 Stockholm (NORDITA), 22 June 2010, and Rome (La Sapienza), 1 July 2010
"Tailoring, counting, and generating sructured random graphs"
 Dublin, 22 June 2011
"Analysis of signalling in large protein interaction networks"
 Evora (Portugal), 16 Sept 2011
"Controlled Markovian dynamics of graphs"
 London, 21 Feb 2012, 26 March 2012
"What you see is not what you get: how sampling affects macroscopic features of
biological networks"
 Stockholm, 12 June 2013
"Generic solution of the competing risk problem in survival analysis"
 Paris, 11 Dec 2013
"Solvable immune network models on
finitely connected graphs with many short loops"
