Professor of Applied Mathematics

Institute for Mathematical and Molecular Biomedicine Hodgkin Building, room HB 4.5N Guy's Campus, London SE1 1UL
Department of Mathematics
Tel: +44 (0)20 7848 6145
Member of the Institute for Mathematical and Molecular Biomedicine (KCL) |

Weekly term-time office hours term II (Strand campus): Thu 9:00-11:00

Statistical mechanics of disordered many-particle systems.

Processes on complex networks and random graphs.

- Medical statistics: Bayesian analysis of survival data in presence of cohort heterogeneity and competing risks
- Mathematical immunology: dynamics and statics of large immune system networks in the finite connectivity regime
- Theory of cellular signaling processes in e.g. proteomic, gene regulatory, and metabolic networks
- Analysis of sparse random graph ensembles
- Equilibrium and non-equilibrium theory of processes on complex finitely connected graphs
- Theory of primary/secondary/tertiary structure generation in hetero-polymers and proteins
- Calculation of the stationary state probability distribution for non-detailed balance spin systems
- Dynamics of econophysical models such as minority games, describing cooperative phenomena in markets.

- J van Baardewijk, H Garmo, M van Hemelrijck, B Grundmark, B Zethelius, L Holmberg and ACC Coolen

*Practical tools for survival analysis with heterogeneity-induced competing risks*

(submitted to Statistics in Medicine, PDF) - J Barrett and ACC Coolen

*Gaussian process regression for survival data with competing risks*

(submitted to Statistics in Medicine, PDF) - J Barrett and ACC Coolen

*Covariate dimension reduction for survival data via the Gaussian process latent variable model*

(submitted to Statistics in Medicine, PDF) - A Shalabi, M Inoue, J Watkins, E De Rinaldis and ACC Coolen

*Bayesian clinical classification from high-dimensional data: signatures versus variability*

(submitted to Statistics in Medicine, PDF) - A Mozeika and ACC Coolen

*Spin systems on hypercubic Bethe lattices: A Bethe-Peierls approach*

(submitted to J Phys A, PDF) - A Annibale, ACC Coolen and N Planell-Morell

*Protein interaction networks and biology: towards the connection*

(submitted to J Phys A, PDF)

ACC Coolen

The
Mathematical theory of minority games - statistical mechanics of
interacting agents

(Oxford University Press, January 2005)

(click here for preface and
detailed list of contents)

ACC Coolen, R Kuehn and P Sollich

Theory
of neural information processing systems

(Oxford University Press, July 2005)

(click here
for preface and detailed list of contents)

in preparation:

ACC Coolen and L Holmberg

Principles of survival analysis

(Oxford University Press, 2013/14)

ACC Coolen, A Annibale and K Roberts

Generating random networks and graphs

(Oxford University Press, 2013/14)

- Utrecht,
22 December 2003

"The trick which became a theory: a brief history of the replica method" - Nara,
21 January, and Tokyo, 3 February 2004

"Disordered (soft) spin systems on random graphs with finite connectivity" - Heidelberg,
1 April 2004

"Simple solvable models of primary and secondary structure formation in hetero-polymers" - Oxford,
27 September 2004, and Amsterdam, 12 November 2004

"Generating functional analysis of minority games with real market histories" - Leiden,
26 May 2005

"Theory of coupled oscillators on finitely connected random networks" - Barcelona,
3 June 2005

"Statistical mechanics of signalling processes on complex biological networks" - Leuven,
8 August 2005

"Finitely connected vector spin systems with random matrix interactions" - Cambridge,
10 Jan 2006

"Dynamics on finitely connected random graphs" - Oxford,
27 Sept 2006

"Generating functional analysis of inner product minority games" - Fribourg,
8 Nov 2007

"Applications of generating functional analysis to minority game models" - Trieste,
16 Jan 2008

"Spin models on random graphs with controlled topologies beyond degree constraints" - Rome,
13 Feb 2008

"A solvable model of the genesis of amino-acid sequences via coupled dynamics of folding and slow genetic variation" - Kyoto,
16 Sep 2009

"Generating functional analysis of complex formation and dissociation in large protein interaction networks" - Stockholm (NORDITA), 22 June 2010, and Rome (La Sapienza), 1 July 2010

"Tailoring, counting, and generating sructured random graphs" - Dublin, 22 June 2011

"Analysis of signalling in large protein interaction networks" - Evora (Portugal), 16 Sept 2011

"Controlled Markovian dynamics of graphs" - London, 21 Feb 2012, 26 March 2012

"What you see isnot what you get: how sampling affects macroscopic features of biological networks" - Bad Honnef (DPG Physics School), Sept 2012

"Counting and generating tailorted random graphs" - Stockholm, 12 June 2013

"Generic solution of the competing risk problem in survival analysis" - Paris, 11 Dec 2013

"Solvable immune network models on finitely connected graphs with many short loops" - Warwick Univ, 5 May 2014

"New approaches to loopy random graph ensembles" - Pisa, 8 Dec 2014

"Bayesian clinical classification from high-dimensional data: signatures versus variability " - Berlin, 14 Jan 2015

Mathematics for cancer research - making optimal use of cancer data" - Torino (Bardonecchia), 2 Feb 2015

"Tools for stochastic processes on loopy networks "

*Akram Shalabi*

Survival analysis and regression from genetic data*Aida Santa Olalla*

Cancer epidemiology

*Harm Jonker, Stephen Laughton, Charles
Mace, Nikos Skantzos, Alexander Heimel, Hirak Chakravorty, Jon
Hatchett, Theodore Nikoletopoulos, Bastian Wemmenhove, Nima Shayeghi,
Sabrina Rabello, Alexander Mozeika, Panos Papadopoulos, Mark Rowley, Kate Roberts, James Barrett*

*Katherine Lawler*

Analysis of gene expression data and integration with optical biomarker information*Mark Rowley*

Bayesian analysis of biomedical data, and their efficient computational implementations.*Kate Roberts*

Statistical mechanics of complex networks and graphs, generation algorithms for networks*Alexander Mozeika*

Mathematical modelling of the immune system

- Neural networks (updated October 1998)
- Information theory in neural networks (updated September 2002)
- Statistical mechanics of neural networks (updated August 1997)
- Advanced neural networks (updated September 2002)
- Introductory quantum theory (updated April 2005)
- Calculus 1 (updated September 2011)
- Markov chains (updated September 2009)
- Path integral methods in the dynamics of disordered spin systems (January 1999)
- Mathematics in 21st century biomedicine (Nov 2009)
- Principles of survival analysis (incomplete) (June 2012)
- Theory of complex networks (November 2014)

- Member of the IOP (Institute of Physics)
- Fellow of the Royal Statistical Society
- Member of the LMS (London Mathematical Society)
- Member of the EPSRC College
- Member of the BBSRC Systems Biology Panel

Academic qualifications:

MSc (Theoretical Physics), Utrecht
1987

PhD (Theoretical Physics), Utrecht 1990

Previous academic appointments:

Postdoctoral fellow, Univ. of Utrecht and Nijmegen, 1990-91

Postdoctoral
fellow, Univ. of Oxford, 1991-95

Reader in
mathematics, King's College London, 1995-2000

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